Configuración óptima de un Mysql Replication Slave con 10GB de Ram, 8 cores y 25GB de SSD

Archivo de configuración para un Mysql 5.6 configurado cómo Slave de Mysql Replication. El servidor tiene 10 GB de RAM, usa 8 Cores Intel y tiene una capacidad de disco SSD de 25GB.
La base de datos contiene tablas en formato MyIsam y InnoDB, con que se han ajustado las dos cache’s apropiadamente.

vim /etc/mysql/mysql.conf.d/mysqld.cnf

Configuración

# Copyright (c) 2014, 2016, Oracle and/or its affiliates. All rights reserved.
#
# This program is free software; you can redistribute it and/or modify
# it under the terms of the GNU General Public License as published by
# the Free Software Foundation; version 2 of the License.
#
# This program is distributed in the hope that it will be useful,
# but WITHOUT ANY WARRANTY; without even the implied warranty of
# MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the
# GNU General Public License for more details.
#
# You should have received a copy of the GNU General Public License
# along with this program; if not, write to the Free Software
# Foundation, Inc., 51 Franklin St, Fifth Floor, Boston, MA  02110-1301 USA

#
# The MySQL  Server configuration file.
#
# For explanations see
# http://dev.mysql.com/doc/mysql/en/server-system-variables.html

[mysqld]
pid-file        = /var/run/mysqld/mysqld.pid
socket          = /var/run/mysqld/mysqld.sock
datadir         = /var/lib/mysql
log-error       = /var/log/mysql/error.log
# Disabling symbolic-links is recommended to prevent assorted security risks
symbolic-links=0
performance_schema = OFF

skip-name-resolve

innodb_buffer_pool_dump_at_shutdown = ON
innodb_buffer_pool_load_at_startup = ON

# INNODB #
innodb-flush-method            = O_DIRECT
innodb-log-files-in-group      = 2
innodb-log-file-size           = 256M
innodb-flush-log-at-trx-commit = 1
innodb-file-per-table          = 1
innodb-buffer-pool-size        = 6G

# CACHES AND LIMITS #
tmp-table-size                 = 32M
max-heap-table-size            = 32M
max-connections                = 500
thread-cache-size              = 50
open-files-limit               = 65535
table-definition-cache         = 4096
table-open-cache               = 1G
query_cache_type        = 1
query_cache_limit       = 3M
query_cache_size        = 256M

# LOGGING #
log-error                      = /var/lib/mysql/mysql-error.log
log-queries-not-using-indexes  = 1
#long_query_time                       = 0.5
slow-query-log                 = 1
slow-query-log-file            = /var/lib/mysql/mysql-slow.log

# MyISAM #
key-buffer-size                = 32M
myisam-recover-options         = FORCE,BACKUP

# * Replication
server-id               = 2
replicate-do-db         = dbeninsoft
replicate-ignore-db     = test
relay-log               = /var/lib/mysql/mysql-relay-bin
relay-log-index         = /var/lib/mysql/mysql-relay-bin.index
log-error               = /var/lib/mysql/mysql.err
master-info-file        = /var/lib/mysql/mysql-master.info
relay-log-info-file     = /var/lib/mysql/mysql-relay-log.info
log-bin                 = /var/lib/mysql/mysql-bin
expire-logs-days        = 3
max-binlog-size         = 500M
slave-skip-errors       = all

optimizer_search_depth = 1